A375-C5
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Description
Description: The cell line A375-C5 is unresponsive to the anti-proliferative effect of IL-1. It has been derived from the parental line A373 (ECACC catalogue no. 88113005) which was subjected to cloning by limiting dilution. This method resulted in the establishment of A375-C5 and an IL-1 sensitive clone, A375-C6 (ECACC catalogue no. 97011321). The unresponsiveness of A375-C5 is probably due to an IL-1 receptor deficiency. The cells have been eradicated from mycoplasma at ECACC.
Also Known As:
Species: Human
Tissue: Skin
Growth Properties: Adherent
Morphology: Epithelial-like
Growth Medium: RPMI 1640 + 2mM Glutamine + 10% FBS
Subculturing Procedure: Split sub-confluent cultures (70-80%) 1:5 using 0.25% trypsin or trypsin/EDTA; 5% CO2; 37°C
Release Conditions: No
Depositor: Dr K Onozaki, Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
Originator: Yes
References: Onozaki K, Matsushima K, Aggarwal BB, Oppenheim JJ 1985 Human interleukin 1 is a cytocidal factor for several tumor cell lines. J Immunol. 135(6):3962-8 PMID: 2415593.
Hyperlink to ECACC Cell Line Data Sheet: 97011320
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