Date added: 19/10/2016 Top Story: The Effects of Diet and Environment on Cancer Susceptibility
THE CELLBANK AUSTRALIA NEWSLETTER
Newsflash
More ECACC Cell Lines
CellBank Australia distributes more than 1,800 cell lines for ECACC to Australian and New Zealand researchers. ** 25 additional ECACC-supplied cell lines are now available from CellBank Australia's online store **. For more information about those 25 lines, click here.
Cell-based Research
Cancer Susceptibility Research: The Effects of Diet and Environment
Researchers have shown that levels of tumour suppressors Deleted in Colorectal Cancer (DCC) and neogenin in cells are depleted by nanomolar concentrations of the serine protease, subtilisin (a chymotryptic protease secreted by the common environmental bacterium Bacillus subtilis and related organisms), and mammalian chymotrypsin itself. The findings identify a potential non-genetic contribution to cancer cell behavior, which may explain both the association of processed meats and other factors with cancer incidence, and the protection afforded by plant-rich diets. The SH-SY5Y, MDA-MB-231 and MCF-7 cell lines and the CACO-2 cells used in the study were purchased from the European Collection of Authenticated Cell Cultures (ECACC; Porton Down, Salisbury, UK).
To read the article, click here.
In Vitro Screening of Silicon Biofortified Leafy Vegetables
Researchers have evaluated the potential health-promoting effects of five silicon-biofortified leafy vegetables on bone mineralization compared with a commercial silicon supplement. Their article was published in the journal, In Vitro Cellular & Developmental Biology - Animal, on 3 October 2016. The CACO-2 cell line was used in the study.
To read the article, click here.
Intranasal Drug Delivery: Evaluation of a Cell Model
Researchers have shown that the RPMI 2650 cell line is a promising alternative to ex vivo or in vivo nasal models for cytotoxicity and evaluation of drug permeability of nasal drug-loaded formulations. Their article was published in the International Journal of Pharmaceutics on 1 October 2016.
To read the article, click here.
Metabolomics Characterization of MDA-MB-231 Cells
Researchers have optimized a method for untargeted metabolomics characterization of MDA-MB-231 triple negative breast cancer cells. Their article was published on 22 September 2016 in the journal, Metabolites. A highly metastatic variant of the MDA-MB-231 triple negative breast adenocarcinoma cell line, MDA-MB-231HM, was used in the study. Its identity was authenticated by CellBank Australia.
To read the article, click here.
Good Cell Culture Practice
The Lab Fridge: Don't Panic!
Karissa Milbury, University of British Columbia graduate student, has spoken about what she found in a lab fridge one morning, and the wonder of bleach. Her article, titled "The Lab Culture: A True Scientific Horror Story," was published in The Science Creative Quarterly on 14 October 2016.
To read the article, click here.
Community Noticeboard
ECACC News
Click here to read the ECACC October 2016 newsletter.
How CellBank Australia can Help
Human Cell Authentication Testing
For human cells, CellBank Australia uses Short Tandem Repeat profiling to examine the number of tetranucleotide repeats at various loci to differentiate cell lines from different donors. CellBank Australia now offers human cell authentication testing for just ** $166 Australian dollars ** per sample, excluding GST.
For more information about our service, click here.